:root{--ink:#233238;--muted:#66767b;--teal:#008c7a;--border:#dfe5e3;--paper:#fff;--bg:#f4f6f3;--orange:#d7652a;--pink:#df9bb0;color-scheme:light;font-family:Arial,Helvetica,sans-serif;color:var(--ink);background:var(--bg)}
*{box-sizing:border-box}body{margin:0}button,input,select{font:inherit}button,a,select,input{touch-action:manipulation}a{color:var(--teal)}button{cursor:pointer;color:inherit}button:focus-visible,a:focus-visible,select:focus-visible,input:focus-visible,summary:focus-visible{outline:3px solid #59b5a9;outline-offset:3px}button:disabled{cursor:default;opacity:.45}[hidden]{display:none!important}p{line-height:1.55}h1,h2,h3,p,figure{margin:0}h2{font-size:21px;font-weight:600;letter-spacing:-.4px}h3{font-size:14px;font-weight:600}button{transition:background .12s,color .12s}a{text-underline-offset:3px}
.masthead{max-width:1480px;padding:23px 44px 17px;margin:auto;display:flex;align-items:center;justify-content:space-between}.brand{display:flex;align-items:center;gap:10px;text-decoration:none;font-size:16px;color:var(--ink);font-weight:600}.brand svg{width:32px;height:32px;fill:none;stroke:var(--teal);stroke-width:1.8}.edition{font-size:12px;color:var(--muted)}main{max-width:1480px;margin:auto;padding:0 44px}.intro{max-width:780px;padding:34px 0 28px}.eyebrow{font-size:11px;text-transform:uppercase;letter-spacing:1.5px;color:var(--teal);font-weight:600;margin-bottom:9px}h1{font-family:Georgia,'Times New Roman',serif;font-size:clamp(35px,4.2vw,58px);font-weight:400;letter-spacing:-1.8px;line-height:1.05;margin-bottom:16px}.intro p{font-size:16px;max-width:690px;color:#526369}.tabs{display:flex;gap:4px;border-bottom:1px solid var(--border);margin-bottom:26px}.tabs button{border:0;background:transparent;padding:15px 22px;color:var(--muted);font-size:14px;border-bottom:3px solid transparent;margin-bottom:-1px}.tabs button.active{color:var(--ink);border-color:var(--teal);font-weight:600}#loading{padding:60px;text-align:center;color:var(--muted)}
#explorer{display:grid;grid-template-columns:265px minmax(0,1fr);gap:25px;align-items:start}.controls{background:white;border:1px solid var(--border);padding:22px;border-radius:5px;position:sticky;top:16px}.controls h2{font-size:18px;margin-bottom:20px}.controls label:not(.rule-list label){display:block;font-size:12px;font-weight:600;margin:20px 0 8px}.controls select{width:100%;padding:11px 26px 11px 10px;background:#fbfcfa;border:1px solid #ccd5d1;border-radius:3px;font-size:13px;color:var(--ink)}.control-note{font-size:12px;color:var(--muted);line-height:1.5;margin-top:11px}.slider-line{margin:14px 0 4px}input[type=range]{width:100%;accent-color:var(--teal);cursor:pointer}.range-labels{display:flex;justify-content:space-between;color:var(--muted);font-size:11px}.fixed-lesion{background:#fbf5f1;display:flex;gap:11px;padding:12px 10px;font-size:13px;margin-bottom:18px}.fixed-lesion span:not(.lesion-dot){display:block;font-size:11px;line-height:1.4;color:var(--muted);margin-top:5px}.lesion-dot{width:9px;height:9px;border-radius:50%;background:var(--pink);flex-shrink:0;margin-top:3px}.rule-list{border:0;padding:0;margin:0 0 14px}.rule-list legend{font-size:12px;font-weight:600;margin-bottom:10px}.rule-list label{display:flex;align-items:center;gap:9px;font-size:13px;padding:9px 5px;cursor:pointer}.rule-list label:has(input:checked){background:#f2f6f3;border-radius:3px;font-weight:600}.rule-list input{accent-color:var(--teal);margin:0}.swatch{display:block;width:16px;height:3px;background:var(--color)}.rule-explanation{font-size:12px;line-height:1.55;color:#53656b;border-top:1px solid var(--border);padding-top:12px;min-height:83px}.rule-explanation .rule-facts{display:flex;gap:10px;margin-top:10px}.rule-facts span{padding:5px 6px;background:#f5f7f5;color:var(--ink);font-size:10px}.anatomy-box{border-top:1px solid var(--border);margin-top:20px;padding-top:17px}.anatomy-box h3{font-weight:500;font-size:12px}.anatomy-box img{display:block;width:100%;height:190px;object-fit:contain;margin:9px 0 4px}.anatomy-key{display:flex;gap:12px;justify-content:center;font-size:10px;color:var(--muted)}.key-dot{display:inline-block;width:5px;height:5px;border-radius:50%;margin-right:3px;background:var(--key-color)}.host{background:#b9c6d0}.lesion{background:var(--pink)}.graft{background:var(--teal)}.text-button{border:0;background:none;color:#49646a;font-size:12px;display:block;padding:8px 0;margin-top:8px;text-align:left}.text-button:hover{color:var(--teal)}
.results{min-width:0;display:grid;gap:22px}.summary-panel,.flight-panel,.dose-panel{background:white;border:1px solid var(--border);padding:24px;border-radius:5px}.section-heading{display:flex;justify-content:space-between;align-items:flex-start;gap:18px;margin-bottom:15px}.section-heading p{color:var(--muted);font-size:12px;margin-top:7px;line-height:1.5}.section-heading .eyebrow{font-size:10px;margin-bottom:6px}.sample-badge{font-size:13px;line-height:1.5;text-align:right;white-space:nowrap}.sample-badge span{display:block;font-size:10px;color:var(--muted)}.summary-description{font-size:13px;color:var(--muted);max-width:660px;margin-bottom:24px}.readouts{display:grid;grid-template-columns:repeat(5,minmax(0,1fr));gap:17px}.readout-title{font-size:11px;color:#4e6066;line-height:1.4;min-height:30px}.readout-value{font-size:26px;font-weight:400;letter-spacing:-.6px;margin-bottom:8px;font-variant-numeric:tabular-nums}.readout-value span{font-size:14px;color:var(--muted);margin-left:2px}.readout-track{position:relative;height:15px;margin:3px 0 8px;background:#f0f3f0;overflow:visible;border-radius:1px}.readout-fill{position:absolute;inset:0 auto 0 0;background:var(--condition-color);opacity:.75}.readout-ref{position:absolute;top:-3px;bottom:-3px;width:1px;background:#67777c}.readout-interval{position:absolute;top:7px;height:1px;background:#243238}.readout-interval:before,.readout-interval:after{content:'';position:absolute;top:-3px;width:1px;height:7px;background:#243238}.readout-interval:after{right:0}.interval-value{font-size:10px;line-height:1.45;color:var(--muted)}.absolute-value{font-size:11px;margin-top:7px;color:#40555c}.chart-note{font-size:11px;color:var(--muted);line-height:1.55;margin-top:15px}.style-controls{display:flex;padding:3px;background:#f1f4f1;border:1px solid #e1e7e2;border-radius:4px;flex-shrink:0}.style-controls button{border:0;background:transparent;padding:7px 10px;font-size:11px;border-radius:3px;color:#5b6c71}.style-controls button.active{background:white;box-shadow:0 1px 3px #22332214;color:var(--ink);font-weight:600}.flight-pair{display:grid;grid-template-columns:1fr 1fr;gap:12px}.flight-pair figure{border:1px solid #e1e7e2;border-radius:3px;overflow:hidden;min-width:0}.flight-pair figcaption{font-size:12px;font-weight:600;padding:11px 12px;background:#fafcf9}.scene-wrap{position:relative;width:100%;aspect-ratio:1.28;background:#f1f4f2}.scene-wrap iframe{border:0;width:100%;height:100%;display:block}.frame-distance{position:absolute;left:10px;bottom:10px;background:#ffffffec;color:#2b4148;padding:5px 7px;font-size:11px;font-variant-numeric:tabular-nums;border:1px solid #dce4df;border-radius:2px}.playback{display:flex;align-items:center;gap:13px;margin-top:15px}.playback button{background:#f6f8f5;border:1px solid #d8e1db;border-radius:3px;padding:7px 10px;font-size:11px;white-space:nowrap}.playback input{flex:1;min-width:40px}.playback output{font-size:12px;color:#49646a;min-width:40px;font-variant-numeric:tabular-nums}.path-details{margin-top:16px;border-top:1px solid var(--border);padding-top:13px}.path-details summary{font-size:12px;cursor:pointer;color:#405b62}.path-details svg{display:block;width:100%;height:auto;max-height:330px;margin-top:12px}.quiet-button{background:transparent;border:1px solid #cddbd5;border-radius:3px;padding:8px 10px;font-size:11px;white-space:nowrap}.quiet-button[aria-pressed=true]{background:#e8f2ee}.curves{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));column-gap:17px;row-gap:20px}.curve h3{font-size:12px;font-weight:500;margin-bottom:7px}.curve svg{display:block;width:100%;height:auto;overflow:visible}.curve svg circle[data-dose]{cursor:pointer}.curve-key{display:flex;gap:12px;flex-wrap:wrap;font-size:10px;margin-bottom:17px;color:var(--muted)}.curve-key span{display:flex;align-items:center;gap:4px}.curve-key i{width:15px;height:2px;background:var(--color)}
.study-notes{margin:35px 0}.study-notes details{border-top:1px solid #d4ded7;padding:18px 0}.study-notes summary{font-size:14px;font-weight:500;cursor:pointer}.study-notes details>p{max-width:850px;font-size:13px;color:var(--muted);margin-top:17px}.notes-grid{display:grid;grid-template-columns:1fr 1fr;gap:28px 40px;margin-top:24px}.notes-grid p{font-size:13px;line-height:1.6;color:var(--muted);margin-top:9px}.source-links{display:flex;gap:23px;margin:20px 0;font-size:12px}footer{max-width:1480px;padding:20px 44px 35px;margin:auto;display:flex;gap:30px;font-size:11px;color:var(--muted);border-top:1px solid var(--border)}footer a{color:var(--muted)}footer span:last-child{margin-left:auto}
@media(min-width:1400px){.scene-wrap{aspect-ratio:1.45}.readouts{gap:24px}}
@media(max-width:1100px){main{padding:0 25px}.masthead{padding-left:25px;padding-right:25px}#explorer{grid-template-columns:235px minmax(0,1fr);gap:18px}.controls{padding:18px}.summary-panel,.flight-panel,.dose-panel{padding:20px}.readouts{gap:10px}.readout-value{font-size:23px}.flight-panel>.section-heading{flex-wrap:wrap}.style-controls{margin-left:auto}.scene-wrap{aspect-ratio:1.1}.curves{grid-template-columns:1fr 1fr}footer{padding-left:25px;padding-right:25px}}
@media(max-width:760px){.masthead{padding:17px 18px}.edition{font-size:10px}.brand{font-size:13px}.brand svg{width:26px;height:26px}main{padding:0 18px}.intro{padding:27px 0 22px}.intro p{font-size:14px}.tabs{gap:0;margin-bottom:18px}.tabs button{font-size:12px;padding:13px 9px;flex:1;line-height:1.5}#explorer{display:block}.controls{position:static;margin-bottom:18px;padding:19px}.controls h2{margin-bottom:12px}.controls select{font-size:14px}.anatomy-box{display:grid;grid-template-columns:1fr 140px;align-items:center;padding-top:12px;margin-top:15px;gap:2px 10px}.anatomy-box img{grid-column:2;grid-row:1/3;width:140px;height:135px;margin:0}.anatomy-key{justify-content:flex-start;flex-wrap:wrap;gap:7px}.controls>.text-button{display:inline-block;margin-right:12px;margin-top:9px}.rule-list{display:grid;grid-template-columns:1fr 1fr}.rule-list label{font-size:12px;padding:10px 6px}.rule-list legend{margin-bottom:5px}.rule-explanation{min-height:0}.results{gap:18px}.section-heading{gap:10px}h2{font-size:19px}.summary-panel,.flight-panel,.dose-panel{padding:19px}.readouts{grid-template-columns:repeat(3,minmax(0,1fr));gap:22px 17px}.readout-title{min-height:20px;font-size:11px}.readout-value{font-size:25px}.flight-pair{gap:7px}.scene-wrap{aspect-ratio:.92}.flight-pair figcaption{padding:10px 8px;font-size:11px;min-height:43px;display:flex;align-items:center}.frame-distance{left:5px;bottom:7px;font-size:10px;padding:4px}.style-controls{margin-left:0}.flight-panel .section-heading p{font-size:11px}.style-controls button{padding:8px 10px}.curves{gap:22px 17px}.dose-panel .section-heading{flex-wrap:wrap}.curve svg{min-height:140px}.notes-grid{grid-template-columns:1fr;gap:24px}.source-links{flex-wrap:wrap;gap:14px}.study-notes{margin:26px 0}footer{padding:20px 18px 30px;flex-wrap:wrap;gap:12px 20px}footer span:last-child{margin-left:0;width:100%}.path-details svg{max-height:none}.summary-description{margin-bottom:21px}.sample-badge{font-size:12px}}
@media(max-width:760px){.curves{grid-template-columns:1fr}.curve h3{font-size:14px}.curve svg{max-height:285px}.path-details svg{max-height:none}}
@media(prefers-reduced-motion:reduce){*{transition:none!important}}

/* A compact study interface, with plot colour reserved for the data. */
:root{--bg:#fff;--muted:#68777c;--border:#e0e5e2;--ink:#26363d}
.masthead{padding-top:22px;padding-bottom:12px}.brand{font-size:15px;font-weight:500}.brand svg{width:27px;height:27px}.edition{font-size:11px}
.intro{max-width:100%;padding:25px 0 22px}h1{font-family:Arial,Helvetica,sans-serif;font-size:34px;font-weight:500;letter-spacing:-.8px;margin-bottom:10px}.intro p{font-size:14px;max-width:750px;color:#64747a}.tabs{margin-bottom:24px}.tabs button{padding:13px 17px;font-size:13px}.tabs button:first-child{padding-left:0;margin-right:18px}
.controls{background:#f7f8f5;border:0;border-top:2px solid #b4c5bd;border-radius:0;padding-top:20px}.controls h2{font-weight:500}.controls select{background:#fff}.rule-list label:has(input:checked){background:#e9eeea}.fixed-lesion{background:none;padding:0 0 15px;border-bottom:1px solid #dce3dd}.rule-explanation{min-height:0;font-size:12px}.anatomy-box img{mix-blend-mode:multiply}
.results{gap:28px}.summary-panel,.flight-panel,.dose-panel{border:0;border-radius:0;padding:0 0 24px;border-bottom:1px solid var(--border)}.section-heading .eyebrow{text-transform:none;letter-spacing:0;font-size:11px;color:#69797e;font-weight:400}.section-heading h2{font-size:20px;font-weight:500}.summary-description{font-size:12px;margin-bottom:22px}.sample-badge{font-size:12px}.readout-title{font-size:12px;min-height:30px}.readout-value{font-size:28px;font-weight:400}.readout-fill{opacity:.72}.readout-track{height:10px}.readout-interval{top:5px}.chart-note{font-size:11px;color:#748287;margin-top:13px}.readouts{gap:25px}
.flight-pair{gap:16px}.flight-pair figure{border:0;border-radius:0}.flight-pair figcaption{background:none;padding:2px 0 10px;font-size:12px}.scene-wrap{border:1px solid #e3e8e4;border-radius:2px}.style-controls{background:none;border:0;gap:3px;padding:0}.style-controls button{background:none;border:1px solid transparent;padding:6px 9px}.style-controls button.active{border-color:#cdd8d1;box-shadow:none;background:#f4f6f3;font-weight:500}.playback{margin-top:13px}.path-details{margin-top:17px}
.curve-actions{display:flex;align-items:center;gap:13px;flex-wrap:wrap}.selection-key{display:flex;align-items:center;gap:7px;font-size:12px;color:#8c3455;white-space:nowrap}.selection-key:before{content:'';display:block;width:10px;height:10px;border-radius:50%;background:#b23c69;border:2px solid white;outline:1px solid #b23c69}.curve-heading{display:flex;align-items:center;justify-content:space-between;gap:7px;min-height:38px;margin-bottom:5px}.curve-heading h3{font-size:13px;font-weight:500;line-height:1.35}.curve-value{font-size:18px;color:#8c3455;text-align:right;font-variant-numeric:tabular-nums;white-space:nowrap}.curve-value small{display:block;font-size:10px;color:#748287;font-weight:400;letter-spacing:0;margin-top:2px}.curve-key{margin-bottom:12px;min-height:15px}.curves{gap:22px 23px}.quiet-button{font-size:11px;padding:6px 9px}.curve svg circle:focus-visible{outline:none;stroke:#26363d;stroke-width:3}
.firing-section{border-top:1px solid #e0e6e1;margin-top:19px;padding-top:17px}.firing-heading{display:flex;align-items:center;justify-content:space-between;gap:12px;margin-bottom:10px}.firing-heading h3{font-size:14px;font-weight:500}.firing-heading span{font-size:11px;color:#6d7e84}.firing-pair{display:grid;grid-template-columns:1fr 1fr;gap:16px}.firing-plot{min-width:0;min-height:150px}.firing-plot svg{display:block;width:100%;height:auto}.firing-section>.chart-note{margin-top:6px;max-width:900px}
.study-notes{margin-top:30px;margin-bottom:25px}.study-notes summary{font-size:13px}.study-notes details{padding:16px 0}footer{font-size:11px;padding-top:19px}
@media(max-width:1100px){.readouts{gap:13px}.curve-heading h3{font-size:12px}.curve-value{font-size:17px}.section-heading h2{font-size:19px}}
@media(max-width:760px){.intro{padding:24px 0 20px}h1{font-size:29px;line-height:1.14;letter-spacing:-.7px}.intro p{font-size:13px}.tabs button{padding:12px 9px;font-size:12px;flex:none}.tabs button:first-child{margin-right:10px}.controls{margin-bottom:23px;padding:18px}.results{gap:23px}.readouts{gap:22px 18px}.readout-title{font-size:11px;min-height:20px}.readout-value{font-size:27px}.summary-panel,.flight-panel,.dose-panel{padding-bottom:22px}.flight-pair{gap:10px}.flight-pair figcaption{min-height:35px;padding-bottom:8px;line-height:1.35}.firing-pair{grid-template-columns:1fr;gap:22px}.firing-plot{min-height:0}.firing-heading{align-items:flex-start;gap:10px}.firing-heading span{font-size:10px}.curve-actions{gap:14px}.curves{gap:25px}.curve-heading h3{font-size:14px}.curve-value{font-size:21px}.curve-value small{font-size:11px}.section-heading{flex-wrap:wrap}.summary-panel .section-heading{flex-wrap:nowrap}.firing-plot svg{max-height:285px}.edition{font-size:10px}}

.edition a{color:inherit}.edition a:hover{color:var(--teal)}.intro p.citation{font-size:12px;color:var(--muted);margin-top:8px}.intro p.citation a{color:var(--teal)}